hillsborough county automated medical argued april decided june appellant hillsborough county adopted ordinances promulgated implementing regulations governing blood plasma centers within county one ordinance requires blood donors tested hepatitis donate one center given test alcohol content donation pursuant public health service act food drug administration fda promulgated federal regulations establishing minimum standards collection blood plasma appellee operator blood plasma center located appellant county filed suit federal district challenging constitutionality ordinances implementing regulations ground inter alia violated supremacy clause seeking declaratory injunctive relief district upheld ordinances regulations except requirement donor subject test appeals affirmed part reversed part holding fda regulations provisions ordinances implementing regulations held appellant county ordinances implementing regulations federal regulations pp intent may inferred comprehensiveness federal regulations regulations issued covered plasma used injections fda indicated regulations issued since time expanding coverage uses affected express disavowal intent state local regulation expansion coverage cast doubt continued validity disavowal even absence disavowal comprehensiveness fda regulations justify infer whenever federal agency deals problem comprehensively tantamount saying whenever agency decides step field regulations exclusive rule inconsistent balance embodied supremacy clause jurisprudence adoption national blood policy sets forth broad statement goals respect blood collection distribution calls cooperation federal government private sector support claim federal regulations grown comprehensive since justify inference complete pp intent inferred purported dominant federal interest field blood plasma regulation factors indicating federal dominance absent regulation health safety matters primarily historically matter local concern national blood policy sufficient indication federal dominance pp concern challenged ordinances impose plasma centers donors requirements stringent imposed federal regulations therefore present serious obstacle federal goal ensuring adequate supply plasma speculative support district findings rejecting appellee factual assertions respect concern lack evidence threat adequacy plasma supply lack statement fda subject adequacy lead conclusion appellant county requirements imperil federal goal record indicate appellee received necessary federal exemption requirement needed collect plasma individuals hepatitis appellee lacks standing challenge ordinances ground conflict federal regulations prevent individuals hepatitis donating plasma pp marshall delivered opinion unanimous emeline acton argued cause appellants briefs joe horn mount paul larkin argued cause pro hac vice amicus curiae urging reversal brief solicitor general lee acting assistant attorney general willard deputy solicitor general geller margaret clark larry stumpf argued cause appellee brief victoria baden richard landfield argued cause american blood resources association et al amici curiae urging affirmance brief william becker benjamin heineman filed brief national association counties et al amici curiae urging reversal briefs amici curiae urging affirmance filed american blood commission michael cardozo grocery manufacturers america peter barton hutt justice marshall delivered opinion question presented whether federal regulations governing collection blood plasma paid donors certain local ordinances appellee automated medical laboratories florida corporation operates subsidiaries eight blood plasma centers one centers tampa plasma corporation tpc located hillsborough county florida appellee plasma centers collect blood plasma donors employing procedure called plasmapheresis procedure whole blood removed donor separated plasma components least red blood cells returned donor cfr appellee sells plasma pharmaceutical manufacturers vendors blood products tpc subject federal supervision public health service act stat amended vendors must licensed secretary health human services hhs licenses issued showing vendor establishment blood products meet certain safety purity potency standards established secretary hhs authorized inspect establishments compliance pursuant act food drug administration fda designee secretary established standards collection plasma cfr regulations require licensed physician determine suitability donor first donation thereafter subsequent intervals longer one year physician must also inform donor hazards procedure obtain donor consent must premises procedure performed addition regulations establish minimum standards donor eligibility specify procedures must followed performing plasmapheresis impose labeling requirements hillsborough county adopted ordinances ordinance imposes license fee plasmapheresis centers within county also requires centers allow county health department reasonable continuing access premises inspection purposes furnish information deemed relevant department see app ordinance establishes countywide identification system requires potential donors obtain county health department identification card valid six months may used plasmapheresis center specified card ordinance incorporates reference fda blood plasma regulations also imposes donor testing recordkeeping requirements beyond contained federal regulations specifically ordinance requires donors tested hepatitis prior registration donate one center given breath analysis alcohol content plasma donation see county promulgated regulations implement ordinance regulations set fee issuance identification card blood donor also establish plasma centers must pay county fee plasmapheresis procedure performed see december appellee filed suit district middle district florida challenging constitutionality ordinances implementing regulations appellee argued primarily ordinances violated supremacy clause commerce clause fourteenth amendment equal protection clause appellee sought declaration ordinances unlawful permanent injunction enforcement november following bench trial district upheld portions local ordinances regulations except requirement donors subject test rejected supremacy clause challenge discerning evidence federal intent whole field plasmapheresis regulation finding conflict hillsborough county ordinances federal regulations addition district rejected claim ordinances violate equal protection clause regulate centers pay donors plasma centers volunteers donate whole blood identified rational basis distinction paid donors sell plasma frequently volunteers donate whole blood paid donors higher rate hepatitis volunteer donors finally district found one exception ordinances impermissibly burden interstate commerce concluded requirement impose large burden plasma centers forcing purchase fairly expensive testing equipment shown achieve purpose adequately served subjective evaluations sobriety already required federal regulations automated medical laboratories appealed appeals eleventh circuit affirmed part reversed part appeals held fda blood plasma regulations provisions county ordinances regulations acknowledged absence express indication congressional intent relying pervasiveness fda regulations dominance federal interest plasma regulation however found implicit intent state local laws subject addition found serious danger conflict fda regulations hillsborough county ordinances reasoning county scheme remains effect national blood policy promoting uniformity guaranteeing continued supply healthy donors adversely affected appeals thus affirmed albeit grounds district invalidation requirement reversed district judgment upholding remaining requirements hillsborough county ordinances regulations view decision reach commerce clause equal protection challenges county scheme ibid hillsborough county county health department appealed pursuant noted probable jurisdiction reverse ii familiar principle supremacy clause art vi cl invalidates state laws interfere contrary federal law gibbons ogden wheat marshall supremacy clause federal law may supersede state law several different ways first acting within constitutional limits congress empowered state law stating express terms jones rath packing absence express language congress intent preempt state law particular area may inferred scheme federal regulation sufficiently comprehensive make reasonable inference congress left room supplementary state regulation rice santa fe elevator whole field also inferred field one federal interest dominant federal system assumed preclude enforcement state laws subject ibid see hines davidowitz even congress completely displaced state regulation specific area state law nullified extent actually conflicts federal law conflict arises compliance federal state regulations physical impossibility florida lime avocado growers paul state law stands obstacle accomplishment execution full purposes objectives congress hines davidowitz supra see generally capital cities cable crisp held repeatedly state laws federal regulations well federal statutes see capital cities cable crisp supra fidelity federal savings loan assn de la cuesta shimer also purposes supremacy clause constitutionality local ordinances analyzed way statewide laws see city burbank lockheed air terminal iii arguing hillsborough county ordinances regulations appellee faces uphill battle first hurdle appellee must overcome fda statement promulgated plasmapheresis regulations intend regulations exclusive response comments expressing concern regulations governing licensing plasmapheresis facilities state local laws governing plasmapheresis fda explained statement accompanying regulations hese regulations intended usurp powers state local authorities regulate plasmapheresis procedures localities fed reg question whether regulation entire field reserved federal government essentially question ascertaining intent underlying federal scheme see supra case appellee concedes neither congress fda expressly state local regulation plasmapheresis thus county ordinances challenged fail must either congress fda implicitly whole field plasmapheresis regulation particular provisions local ordinances conflict federal scheme according appellee two separate factors support inference federal intent whole field pervasiveness fda regulations dominance federal interest area appellee also argues challenged ordinances reduce number plasma donors effect conflicts congressional goal ensuring adequate supply plasma fda statement dispositive question implicit intent unless either agency position inconsistent clearly expressed congressional intent see chevron natural resources defense council subsequent developments reveal change position given appellee first argument implicit comprehensiveness fda regulations evinces intent effect must result change since comprehensiveness federal regulations prevail second argument implicit dominance federal interest plasmapheresis regulation appellee must show either interest became compelling since fda seriously underestimated federal interest plasmapheresis regulation second obstacle appellee path presumption state local regulation matters related health safety invalidated supremacy clause challenged ordinances hillsborough county attempted protect health plasma donors preventing donating frequently see brief appellants also attempted ensure quality plasma collected protect turn recipients plasma field congress said traditionally occupied start assumption historic police powers superseded federal act unless clear manifest purpose congress jones rath packing quoting rice santa fe elevator citations omitted cf kassel consolidated freightways deference state regulation safety dormant commerce clause brennan concurring judgment rehnquist dissenting course principles apply field said agency acting pursuant congressional delegation appellee must thus present showing implicit whole field conflict particular local provision federal scheme strong enough overcome presumption state local regulation health safety matters constitutionally coexist federal regulation iv given clear indication fda intention deference must review challenged ordinances conclude ordinances federal scheme reject argument intent may inferred comprehensiveness fda regulations issue pointed given fda statement relevant inquiry whether finding justified increase since comprehensiveness federal regulations admittedly regulations broadened years adopted regulations covered plasma used injections regulations expanded cover also plasma used manufacture noninjectable products fed reg original regulations also amended clarify strengthen existing source plasma human regulations light fda inspectional regulatory experience ibid see also fed reg first proposing amendments fda indicated new regulations affected disavowal intent state local regulation fact federal scheme expanded reach uses plasma cast doubt continued validity disavowal indeed even absence statement comprehensiveness fda regulations justify new york dept social services dublino stated subjects modern social regulatory legislation often nature require intricate complex responses congress without congress necessarily intending enactment exclusive means meeting problem upholding state provisions challenge noted federal provisions sufficiently comprehensive authorize govern programs requirements well cooperatively requirements ibid merely federal provisions sufficiently comprehensive meet need identified congress mean localities barred identifying additional needs imposing requirements field see also de canas bica even reluctant infer comprehensiveness regulations comprehensiveness statutes result specialized functions agencies normally deal problems far detail congress infer whenever agency deals problem comprehensively virtually tantamount saying whenever federal agency decides step field regulations exclusive rule course inconsistent balance embodied supremacy clause jurisprudence see jones rath packing moreover agencies normally address problems detailed manner speak variety means including regulations preambles interpretive statements responses comments expect make intentions clear intend regulations exclusive thus agency speak question pause saying mere volume complexity regulations indicate agency fact intend given presumption state local regulation related matters health safety normally coexist federal regulations seldom infer solely comprehensiveness federal regulations intent entirety field related health safety appellee also relies promulgation national blood policy department health education welfare hew indication federal regulatory scheme comprehensive enough justify complete see brief appellee reliance misplaced national blood policy established pluralistic evolutionary approach solution blood collection distribution problems fed reg policy contains regulations instead broad statement goals call cooperation federal government private sector policies intended achieve certain goals detail methods implementation developing effective suitable means reaching goals secretary involve appropriate relevant public private sectors federal government agencies cooperative effort provide best attainable blood services appellee second argument whole field plasmapheresis regulation intent inferred dominant federal interest field unpersuaded argument undoubtedly every subject merits congressional legislation definition subject national concern mean however every federal statute ousts related state law neither supremacy clause require us rank congressional enactments order importance hold top scale federal regulation must exclusive instead must look special features warranting case law provides us clear standards guide inquiry area example seminal case hines davidowitz inferred intent dominance federal interest foreign affairs supremacy national power general field foreign affairs made clear constitution regulation field intimately blended intertwined responsibilities national government see also zschernig miller needless say factors absent rather stated regulation health safety matters primarily historically matter local concern see rice santa fe elevator also merit appellee reliance national blood policy indication dominance federal interest area nothing policy takes plasma regulation category converts area overriding national concern appellee final argument even regulations comprehensive enough federal interest dominant enough entire field plasmapheresis regulation hillsborough county ordinances must struck conflict federal scheme appellee argues principally challenged ordinances impose plasma centers donors requirements stringent imposed federal regulations therefore present serious obstacle federal goal ensuring adequate supply plasma tr oral arg see brief appellee fed reg find concern speculative support appellee claims evidence trial indicated enforcement county ordinances result increase direct costs plasma production per litre total increase production costs including direct indirect costs per litre plasma increase approximately total cost production brief appellee appellee argues increased financial burdens reduce number plasma centers addition appellee claims county requirements reduce number donors occasionally sell plasma donors deterred requirement basis record district rejected appellee factual assertions district found appellee estimates clouded speculation app also found appellee presented facts support conclusion vendor population decrease percent ibid findings fact set aside clearly erroneous fed rule civ proc see anderson bessemer city hence come us strong presumption validity importantly even hillsborough county ordinances fact reduced supply plasma county necessarily follow interfere federal goal maintaining adequate supply plasma undoubtedly overly restrictive local legislation threaten national plasma supply neither congress fda however struck particular balance safety quantity noted regulations contemplated additional state local requirements merely establish minimum safety standards see fed reg supra moreover record case indicate supply federal government considers adequate reason believe reduction quantity plasma donated make supply inadequate finally fda possesses authority promulgate regulations local legislation imperils supply plasma relative ease see supra moreover agency expected monitor continuing basis effects federal program local requirements thus since agency suggested county ordinances interfere federal goals reluctant absence strong evidence find threat federal goal ensuring sufficient plasma analysis somewhat different congress delegated fda administration federal program congress unlike agency normally follow years enactment federal legislation effects external factors goals federal legislation sought promote moreover difficult congress make intentions known example amending statute agency amend regulations otherwise indicate position summary given findings district lack evidence record threat adequacy plasma supply significance attach lack statement fda conclude hillsborough county requirements imperil federal goal ensuring sufficient plasma appellee also argues county ordinances conflict federal regulations prevent individuals hepatitis donating plasma see supra plasma used production hepatitis vaccines federal regulations provide collection pursuant special authorization carefully controlled conditions cfr extent hillsborough county ordinances preclude individuals hepatitis donating plasma ordinances said stand way accomplishment federal goal combating hepatitis order collect plasma individuals hepatitis however plasma center must obtain fda pursuant exemption requirements record indicate appellee received required exemption result appellee collect plasma individuals hepatitis even absence county ordinances thus appellee lacks standing challenge ordinances ground hold hillsborough county ordinances implementing regulations scheme federal regulation plasmapheresis judgment appeals eleventh circuit therefore reversed case remanded proceedings consistent opinion ordered footnotes appellee argue inferred comprehensiveness federal statutes governing plasmapheresis amendments regulations indicate fda departing earlier statement changes technical provide basis inferring intent federal regulation exclusive follows fda statement underestimate federal interest plasmapheresis regulation two amici argue county ordinances interfere federal interest uniform plasma standards merit argument federal interest stake ensure minimum standards uniform standards indeed fda statement makes clear additional nonconflicting requirements interfere federal goals found reason doubt continued validity statement see supra since ordinances incorporate fda regulations see supra may fact also provide type exemptions authorized cfr ordinances interpreted way course conflict